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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod

Fig. 4

DSS-treated mice exhibit increased inflammatory markers in the serum by day 7 but endotoxin levels remain low. Serum was isolated from male and female control and DSS-treated mice at the indicated time points or mice injected with 100 μg LPS for 24 h. IL-6 and KC levels were quantified by CBA and S100A8/A9 levels were measured by ELISA (A–C). Serum isolated on day 7 from DSS-treated mice or 24 h after injection with 0.5 mg/kg LPS was inactivated, diluted 50-fold in endotoxin-free water and endotoxin levels were quantified (D). Student’s t test comparing DSS or LPS to control. *** = p < 0.0005, ** = p < 0.005, * = p < 0.05

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Journal of Neuroinflammation

ISSN: 1742-2094