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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Administration of anti-ERMAP antibody ameliorates Alzheimer’s disease in mice

Fig. 2

Anti-ERMAP mAb improves cognitive performance in AD mice. Female 3XTg-AD mice (12-month-old) were injected i.p. with anti-ERMAP mAb or isotype Ab once a week. Three months later, the mice were evaluated for cognitive performance by Barnes Maze and NOR tests. A The escape latency during the training period, and B and C the escape latency and the number of errors committed during the probe trial are shown. D NOR index was determined as the time spent interacting with the novel object divided by the total time of exploration during the testing phase. The data are expressed as mean ± SD from one of three independent experiments with similar results (5 to 8 mice per group in each experiment). *P < 0.05 versus isotype Ab group

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