Fig. 2
Cx3cr1CreER IL-10−/−mice showed a decrease recognition impairment in MWM task. a Representative movement traces from two groups during the training stage of the MWM task. Cx3cr1CreERIL-10−/−mice had more dispersed paths in the training stage, suggesting impairments in learning ability. There was a significant increase in escape latency (b) and average distance (c) in Cx3cr1CreERIL-10−/− mice in the training stage, while Cx3cr1CreERIL-10−/− mice swam faster in the MWM task (d). e Representative movement traces from the two groups on the test stage of the MWM task. Cx3cr1CreERIL-10−/−mice had more dispersed paths in the test stage, suggesting memory impairments. There was a significant decrease in both the platform crossover times (f) and time spent in the target quadrant (g) in the Cx3cr1CreERIL-10−/− group in the test stage, while the swimming speed was similar between the two groups during the test stage (h). Each dot represents a mouse. Bars represent mean ± SEM. n = 8 in each group. Significant differences were established by two-way ANOVA (b–d) and t-test in other bar graphs, *P < 0.05