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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice

Fig. 6

The effects of knocking out IL-10 from Microglia in interneuron and the increase of TRPC5 in excitatory neuron. a Western blotting bands of GAD67 and parvalbumin in littermates and in Cx3cr1CreER IL-10−/−mice. Bar graphs represent densitometric plots of protein expression in littermate and Cx3cr1CreERIL-10−/−mice in GAD67 (b) and parvalbumin (c). Each dot represents a mouse. Bars represent mean ± SEM. n = 4 in each group. Significant differences were established by t-test. d Colocalization of TRPC5 and CaMKIIα in CA3 region in hippocampal slices. Immunofluorescence images, captured with a 20 × objective. Green, immunoreactivity of TRPC5; red, immunoreactivity of CaMKIIα, a marker of excitatory neurons, blue, nuclei staining with DAPI. The merged images of TRPC5, CaMKIIα and DAPI staining. ***P < 0.001

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