Fig. 3From: Systemic inflammasome activation and pyroptosis associate with the progression of amnestic mild cognitive impairment and Alzheimer’s diseaseActivation of proteins related to inflammasomes and pyroptosis in PBMCs isolated from patients with AD and controls. a Expression and activation of NLRP3, caspase-1, GSDMD, and IL-1β in PBMCs as determined by Western blot analysis. b–h Quantification of relative protein levels shown in a. i Immunofluorescence analysis of GSDMD (N-terminus) in PBMCs isolated from a representative AD patient and control. j Quantification of positive cells shown in i. *P < 0.05, **P < 0.01, ***P < 0.001 versus control group, #P < 0.05, ##P < 0.01 versus aMCI group. Data are expressed as means ± SEM (n = 3). One-way ANOVA for b–h. Unpaired t test for jBack to article page