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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Systemic inflammasome activation and pyroptosis associate with the progression of amnestic mild cognitive impairment and Alzheimer’s disease

Fig. 3

Activation of proteins related to inflammasomes and pyroptosis in PBMCs isolated from patients with AD and controls. a Expression and activation of NLRP3, caspase-1, GSDMD, and IL-1β in PBMCs as determined by Western blot analysis. bh Quantification of relative protein levels shown in a. i Immunofluorescence analysis of GSDMD (N-terminus) in PBMCs isolated from a representative AD patient and control. j Quantification of positive cells shown in i. *P < 0.05, **P < 0.01, ***P < 0.001 versus control group, #P < 0.05, ##P < 0.01 versus aMCI group. Data are expressed as means ± SEM (n = 3). One-way ANOVA for bh. Unpaired t test for j

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