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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: A new experimental design to study inflammation-related versus non-inflammation-related depression in mice

Fig. 1

HFD mice displayed expected overweight and related metabolic dysregulations as compared to SD-fed mice. A Experimental timeline and design. Male C57BL/6J mice (3 weeks old) were fed ad libitum as soon as they arrived and during the entire experiment with standard diet (SD; 2.9 kcal/g) or high-fat diet (HFD; 5.24 kcal/g). Behavioral measures included: coat-state, splash-test, novelty suppressed feeding test (NSFT), sucrose preference test (SPT), locomotor activity and forced swim test (FST). n = 32/group before UCMS onset and 14–16/group after. B Schematic representation of the different stressors randomly applied during the UCMS procedure. C Body weight was recorded weekly for the entire experiment. It became significantly higher in HFD mice than in their SD counterparts from the 9th week. ***P < 0.001 for Diet effect

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