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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Tonicity-responsive enhancer-binding protein promotes diabetic neuroinflammation and cognitive impairment via upregulation of lipocalin-2

Fig. 9

Graphical summary of the proposed role of TonEBP in diabetes-induced neuroinflammation and memory deficits. During chronic diabetic conditions, systemic inflammation causes infiltration of neutrophils through blood–brain barrier leakage. This LCN2 production during chronic diabetes promotes TonEBP-mediated neuroinflammation, ultimately leading to memory deficits. In particular, TonEBP transcriptionally regulates LCN2 protein levels under diabetic conditions

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Journal of Neuroinflammation

ISSN: 1742-2094