Fig. 1
taken from Allen Institute. Scale bar = 150 μm. Data are presented as mean ± SEM of 10–12 mice per treatment group (5–7 per sex per group). Two-way ANOVA with repeated measures with Holm–Sidak’s post hoc test was used to compare to PS19-Saline controls. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001
Effect of TNF-α inhibitors on pTau (Ser202, Thr205) in the PS19 mice. Schematic showing the experimental timeline for treatment and sample processing of the PS19 mice. Figure was prepared using BioRender.com (A). AT8-positive area in different brain regions in male (B) and female (C) mice. The overall AT8-positive area, which is an average of the regional AT8-positive area, was significantly reduced by etanercept in both sexes and by TfRMAb-TNFR in female mice (B, C). Representative images of AT8-positive pTau in PS19 mice (D). The thumbnail brain section images showing the hippocampus (red box) and amygdala (black box) in D are