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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Biologic TNF-α inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy

Fig. 5

Plasma pharmacokinetic (PK) profile. Experimental design (top panel) and plasma concentration–time curves (bottom panel) following a single IP 1.75 mg/kg dose of TfRMAb-TNFR or IP 0.875 mg/kg dose of etanercept in C57BL/6 J mice (A). Experimental design (top panel) and plasma concentration–time curves (bottom panel) following chronic TfRMAb-TNFR dosing (B). Schematics in A and B were prepared using BioRender.com. For chronic TfRMAb-TNFR treatment, APP/PS1 mice were treated with a single 1.75 mg/kg IP injection after chronic 4-week treatment with saline (single injection group) or 1.75 mg/kg TfRMAb-TNFR (chronic injection group) and plasma samples were collected at 3 h, 6 h and 24 h following injection (B). Data are shown as the mean ± SEM of n = 4–6 mice per treatment group per time point

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Journal of Neuroinflammation

ISSN: 1742-2094