Fig. 6

Complete blood count (CBC). A CBC was performed following a single 1.75 mg/kg TfRMAb-TNFR IP injection in male C57BL/6J mice (A) or chronic 8-week treatment with saline, 1.75 mg/kg TfRMAb-TNFR or 0.875 mg/kg etanercept in the male and female PS19 mice (B). For CBC analysis, red blood cell (RBC, i), hematocrit (Hct, ii), hemoglobin (HGB, iii), reticulocytes (iv), mean corpuscular volume (MCV, v), platelets (vi), and white blood cells (WBC) (B, viii) were measured. WBC counts were not measured following the single injection study. Sexes were combined for chronic CBC data due to no sex-related effects. The body weights of age-matched WT-Saline and PS19 mice were measured weekly. No significant difference was observed between the baseline and terminal body weights of the mice in any experimental group (C). For CBC data following a single injection (A), the two-sample t test was used to compare to the WT-Saline mice (n = 3 mice per group). Two-way repeated-measures ANOVA with Holm–Sidak’s post hoc test was used for CBC data after 8-week treatment to compare to PS19-Saline mice (n = 4–6 mice per group) (B) and body weight changes (n = 5–7 mice per group) (C). **p < 0.01, ****p < 0.0001