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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Down-regulation of circular RNA CDC14A peripherally ameliorates brain injury in acute phase of ischemic stroke

Fig. 6

Knocking down the expression of circCDC14A in peripheral blood cells. a Flow chart of the experiment design. b Colocalization of GFP lentivirus with Ly6g 6 days after tail vein injection. Bar: 20 μm. c Expression of circCDC14A in peripheral white blood cells, n = 6 mice per group. ****P < 0.0001, Student’s t test. d Measurement of infarct volume by TTC staining on 72 h after tMCAO, n = 8 mice per group. **P < 0.01, Student’s t test. e Neurological deficit score of tMCAO mice in 1 day, 3 days, 5 days and 7 days after modeling. CircCon n = 16, si-circCDC14A n = 18. ****P < 0.0001, two-way ANOVA test. f Kaplan–Meier curve of tMCAO mice in 7 days after modeling. CircCon n = 25, si-circCDC14A n = 25. ***P < 0.001, log rank test

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