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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Down-regulation of circular RNA CDC14A peripherally ameliorates brain injury in acute phase of ischemic stroke

Fig. 7

Activation of astrocytes in peri-infarct cortex of tMCAO mice in 7 days after modeling. a Representative images of immunofluorescence showing activated astrocytes (GFAP) and neutrophils (Ly6g) in peri-infarct cortex 3 days after modeling. Dashed line showed the border of the infarct lesion. Bar: 100 μm. Density of activated astrocytes in peri-infarct cortex were analyzed, n = 5 field (200 μm × 200 μm) *6 different mice represented by different colors per group. ****P < 0.0001, Student’s t test. b 3D-reconstruction (Imaris) of a representative astrocyte cell per region 3 days after modeling. Areas and volumes of activated astrocytes in peri-infarct cortex were analyzed by Imaris software, n = 5 astrocytes (200 μm × 200 μm) *6 different mice represented by different colors per group. ****P < 0.0001, Student’s t test. c Representative images of immunofluorescence showing activated astrocytes (GFAP) and neutrophils (Ly6g) in peri-infarct cortex 5 days after modeling. Bar: 100 μm. Density of activated astrocytes in peri-infarct cortex were analyzed, n = 5 field (200 μm × 200 μm) *4 different mice represented by different colors per group. ****P < 0.0001, Student’s t test. d 3D-reconstruction (Imaris) of a representative astrocyte cell per region 5 days after modeling. Areas and volumes of activated astrocytes in peri-infarct cortex were analyzed by Imaris software, n = 5 field (200 μm × 200 μm) *4 different mice represented by different colors per group. ****P < 0.0001, Student’s t test. e Representative images of immunofluorescence showing activated astrocytes (GFAP) and neutrophils (Ly6g) in peri-infarct cortex 7 days after modeling. Bar: 100 μm. Density of activated astrocytes in peri-infarct cortex were analyzed, n = 5 field (200 μm × 200 μm) *5 different mice represented by different colors per group. ****P < 0.0001, Student’s t test. f 3D-reconstruction (Imaris) of a representative astrocyte cell per region 7 days after modeling. Areas and volumes of activated astrocytes in peri-infarct cortex were analyzed by Imaris software, n = 5 field (200 μm × 200 μm) *5 different mice represented by different colors per group. **P < 0.01, Student’s t test

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