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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology

Fig. 4

The sTREM2 fragment 41–81 increases the number of plaque-associated microglia. A, C Coronal sections from the 5xFAD mice injected with the Fc-tagged sTREM2 fragments (A, the sTREM2 fragment 41–81; C, the sTREM2 fragment 51–81) or Fc alone were stained with DAPI (blue) for nuclei, MOAB-2 (green) for Aβ, and Iba1 (red) for microglia. Representative z-stack images of the hippocampus regions are shown. Original magnification× 60; scale bar, 50 μm. B Quantitation of the number of plaque-associated microglia in the presence of sTREM2 fragment 41–81 (n = 5 mice, 55 plaques of Fc and 43 plaques of 41–81, paired Student’s t test). D Quantitation of the number of plaque-associated microglia in the presence of sTREM2 fragment 51–81 (n = 5 mice, 47 plaques of Fc and 47 plaques of 51–81, paired Student’s t test)

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