Fig. 3

Double immunostaining for ATPB (green) and CaMKII (red) in the cerebral cortex of 15-week-old SAMR1 mice (A–C) and 5-week-old (D–F), 15-week-old (G–I) and 25-week-old (J–L) SAMP10 mice. M Quantification of the immunofluorescent signals. Note that the ATPB signal had greatly increased and was localized to the neurons at 15 weeks of age, but dramatically decreased at 25-week-old. Arrowheads indicate ATPB signals. Scale bar: 10 μm. Data are means ± SEs. They were analyzed by one-way ANOVA followed by the Bonferroni test (**p < 0.01). n = 4 for each group, except for 25-week-old SAMP10 mice (n = 2)