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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease

Fig. 2

p38 inhibitor SB203580 inhibits the activation of NLRP3 inflammasome. A IHC demonstrating SB203580 reduced NLRP3 protein levels in the cortex and SNpc of 9-month-old α-synucleinA53T-tg mice. Scale bars, 100 μm. B Statistical analysis of the scores of NLRP3 staining between α-synucleinA53T-tg and wild-type mice. *p < 0.05. C IHC demonstrating SB203580 reduced IL-1β protein levels in the cortex and SNpc of 9-month-old α-synucleinA53T-tg mice. Scale bars, 100 μm. D Statistical analysis of the scores of IL-1β staining between α-synucleinA53T-tg and wild-type mice. *p < 0.05. E–G Cell lysates from the cortex and SNpc of mice were immunoblotted using the indicated antibodies. The protein levels of NLRP3, ASC, cleaved CASP1 were statistically analyzed in F and G. *p < 0.05

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Journal of Neuroinflammation

ISSN: 1742-2094