Skip to main content
Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease

Fig. 6

α-Synuclein-induced NLRP3 activation in microglia promoted dopaminergic neuronal loss. A, B Immunohistochemistry (IHC) demonstrating the levels of IBA-1 in the SNpc of 9 months of wild type, α-synuclein A53T-tg and α-synuclein A53T-tg mice treated with MCC950. Statistical analysis of the scores of IBA-1 staining is shown in B. Scale bars, 100 μm. Mean ± SEM, n = 3. *p < 0.05. C, D Immunohistochemistry (IHC) demonstrating the levels of TH in the SNpc of 9 months of wild type, α-synuclein A53T-tg and α-synuclein A53T-tg mice treated with MCC950. Statistical analysis of the levels of TH staining is shown in D. Scale bars, 100 μm. Mean ± SEM, n = 3. *p < 0.05. E Balance beam foot slips were quantified after PBS or SB203580 injection. F Results of the pole test were quantified after PBS or SB203580 injection. G, H Cell lysates from the SNpc and cortex of mice were immunoblotted using the α-synuclein and TH antibody. Mean ± SEM, n = 6, *p < 0.05. I, J TEM was used to examine the number of synapses. The provided scale bar in merge the image represented 500 nm

Back to article page