Fig. 6
Deletion of MOR or DOR in Nav1.8-expressing sensory neurons does not impact inflammatory visceral pain in mice treated with 3% DSS for 5 days. Conditional knockout mice (black symbols) for either MOR (MOR cKO) (A–C) or DOR (DOR cKO) (D–F) were compared to their corresponding littermate wild-type floxed mice (MOR flox and DOR flox) (white symbols) (n = 7–10 mice/group) on day 5 of the 3% DSS treatment for visceral sensitivity (A and D), colitis severity assessed by colon wall thickness and macroscopic tissue damage (B and E) and mucosal CD3+ T lymphocyte density (each point, corresponding to one animal, represents the mean of four different histological examinations per slice) (C and F) (n = 4–8 mice/group). Data are expressed as mean ± SEM. Statistical analysis was performed using repeated-measures two-way ANOVA (A and D) or Mann–Whitney U test (B, C, E and F)