Fig. 4
From: Pericytes as mediators of infiltration of macrophages in multiple sclerosis
Inflammatory potential of pericytes. A–P Pericytes, when stimulated with the inflammatory cocktail of IL-1β and IFN-γ (10 ng/mL each), and CSPGs (10 µg/mL), secrete a plethora of cyto-chemokines, as exhibited by Multiplex ELISA (TNF-α was assayed separately using an ELISA kit). While G-CSF (A), GM-CSF (B), CCL11 (eotaxin) (D), RANTES (F), CXCL10 (IP-10) (G), CXCL1 (H), LIF (J), CXCL9 (K) and VEGF (L) are upregulated in response to IL-1β + IFN-γ, CSPGs specifically increased TNF-α (E), IL-6 (I), CCL2 (MCP-1) (M), and MIP-2, CCL3 and CCL4 proteins (N–P) in the cultured pericytes. Concentrations are expressed as pg/mL. Data are represented as mean ± SD. *p < 0.05, **p < 0.01