Fig. 2From: A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampusMicroglial activation and PGD2 production observed in the hippocampus of WT and GPR120 KO mice. The protein level determined by western blot analysis (A). The level of Iba-1 protein in the hippocampus (B). The immunofluorescence of Iba-1 (C–E) and Iba-1 positive cell counts in the CA3 (D) and hippocampus (E). Scale bar = 50 μm. PGD2, PGE2, and PGF2α contents (F) in the hippocampus. PGD2 contents in each tissue (G). The level of COX-1 (H), COX-2 (I), L-PGDS (J), and H-PGDS (K) protein in the hippocampus. Data are means ± SEM, n = 5 per group. Statistical analysis was performed using unpaired Student's t test (*p < 0.05; **p < 0.01; ***p < 0.001 vs. WT)Back to article page