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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus

Fig. 7

Dysfunction of peripheral GPR120 caused PGD2-microglia-provoked neuroinflammation and neurodegeneration in the hippocampus. Peripheral GLP-1 by intestinal GPR120 stimulation remotely contributed to hippocampal homeostasis via suppression of PGD2-microglia-provoked neuroinflammation in WT mice. However, insufficient GLP-1 bioactivity caused by GPR120 dysfunction induced PGD2-microglia-provoked neuroinflammation and neurodegeneration in GPR120 KO mice

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Journal of Neuroinflammation

ISSN: 1742-2094