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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation

Fig. 5

Genetic ablation of microglia in Cx3cr1-iDTR mice does not cause brain parenchyma swelling or edema. A MRI measures of 3D parenchyma volume show no difference in genetic microglia ablated mouse brains compared to Cx3cr1-Cre or iDTR brains after Dtx treatment. B Water content does not change among Cx3cr1-Cre, Cx3cr1-iDTR or iDTR brains. CH Diffusion parameters calculated from DTI data show no differences between microglia ablated (Cx3cr1-iDTR) and control (Cx3cr1-Cre) animals in striatum, cortex and corpus callosum. (Each data point represents an individual animal. Mean + SEM. No significant difference among any of the groups one-way or two-way ANOVA with Tukey post-hoc analysis). A and B data pooled from two independent experiments and CH from a single experiment

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