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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation

Fig. 7

Genetic ablation of microglia in Cx3cr1-iDTR mice does not lead to neurodegeneration in the somatosensory and motor cortex. A Representative cortical images showing NeuN staining at 1 day after a 3 day Dtx treatment regimen. B Quantification of NeuN stereological estimates for cell density in each cortical layer. No statistical difference was found among groups at any cortical layer (N = 3–6 for each group, Mean ± SEM, One-way ANOVA for each layer among three groups). Quantification result is from one cohort of mice with similar results observed from > 2 other independent experiments

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Journal of Neuroinflammation

ISSN: 1742-2094