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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Social isolation induces neuroinflammation and microglia overactivation, while dihydromyricetin prevents and improves them

Fig. 1

DHM reduces social isolation-induced anxiety. A Effects of social isolation and treatment with DHM on anxiety-like behaviors as measured by the time (min) spent in the open and closed arms of the elevated plus-maze. B Effects of social isolation and treatment with DHM on locomotor activity, exploratory behaviors as measured by running distance (total distance of moving), rearing (total number of times of rearings), corner (the total duration the mouse stayed in the 4-corner 10 × 10 cm squares), and center time (the total time duration the mouse stayed in the center 20 × 20 cm square), in the open field assay. One-way ANOVA followed by multiple comparison, Holm–Sidak method to the control. For running length, p < 0.001; for numbers of rearings, p  < 0.001. For stay in corners p  < 0.001. For stay in the center, p  < 0.001. * = p  ≤ 0.05 vs. vehicle group housing control (G2 + Veh2). (n = 10–11/group)

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