Fig. 7

SNHG15 is an anti-inflammatory molecule in mice. The levels of IL-4 (A), IL-10 (B), IL-6 (C), and TNF-α (D) in plasma were measured by ELISA. Expression of IL-4 (E), IL-10 (F), IL-6 (G), and TNF-α (H) was detected by qRT-PCR in PBMCs. I, J Effects of SNHG15 knockdown on cerebral injury 3 days post-stroke. K Neurological function was assessed 1, 3 and 7 days after tMCAO. The modified neurological severity score (mNSS) was used by investigators blinded to the tMCAO and control groups to assess neurological deficits; the assessment included the tail suspension test, locomotor test, beam walking test and reflex test. Neurological function was graded on a scale of 0 to 14 points, and higher scores indicated more severe neurological deficits. SNHG15 expression in PBMCs (L) and brain tissues (M). N Effects of SNHG15 knockdown on the STAT6, TRAF2, NF-κB, and MAPK pathways 3 days post-stroke. O–R Effects of silencing SNHG15 on the expression of inflammatory factors 3 days post-stroke. * P < 0.05, ** P < 0.01, *** P < 0.001