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Table 1 Characteristics HCs, DCs, and patients with MS, NMOSD, and MOG-AD

From: Dysregulated B cell differentiation towards antibody-secreting cells in neuromyelitis optica spectrum disorder

  HC MS NMOSD MOG-AD DC (CSF) MS (CSF) NMOSD (CSF)
Number 27 22 24 11 12 9 8
Age 38 (22–60) 34 (22–54) 46 (24–65) 36 (17–66) 51 (30–72) 39 (23–53) 43 (39–74)
Male: female 6:21 5:17 2:22 3:8 6:6 2:7 1:7
disease duration (months)   56 (0–118) 53 (0–173) 35 (0–78)   51 (0–118) 47 (0–162)
Age of symptom onset   29 (19–52) 38 (20–63) 50 (16–66)   33 (19–52) 39 (26–63)
Medications        
 Naïve   15 0 4   6 1
 IFNβ, n   4     2  
 Glatiramer acetate, n   2     0  
 Dymethyl fumarate, n   1     1  
 Prednisone, n   0 22 7   0 5
 Daily dose of prednisone, median (mg/day)    7 5 (3–7)    8 (5–14)
 Tacrolimus, n   0 4 0   0 3
 Azathioprine, n   0 4 0   0 0
 Mizoribine, n   0 1 0   0 0
      Normal pressure hydrocephalus n = 1
Cerebral venous thrombosis n = 1
Old cerebral infarction n = 4
causeless sensory abnormality n = 2
Parkinson disease n = 4
  
  1. IFNβ: interferon-β