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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: MORPHIOUS: an unsupervised machine learning workflow to detect the activation of microglia and astrocytes

Fig. 5

Focal and proximal microglia differentially upregulate common markers of activation. Focal (red line) microglia (A) colocalized with TGFβ1 (B, D), and CD68 (C, D). Proximal (orange line) microglia colocalized with TGFβ1, but not CD68. Pearson correlation was used to colocalize IBA1 with TGFβ1 (E) and CD68 (F). Images (A–C) were taken at 20× magnification. Insets (D1–D4) were taken at 63× magnification. Groups were analyzed via a mixed linear model. Scale bar: 100 µm. CD68, cluster of differentiation 68; Contra., contralateral; IBA1, ionized calcium-binding adapter molecule 1, Prox., proximal; TGFβ1, transforming growth factor beta 1,

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