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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Innate immune stimulation by monophosphoryl lipid A prevents chronic social defeat stress-induced anxiety-like behaviors in mice

Fig. 6

Effect of minocycline pretreatment on MPL-induced acute neuroinflammatory response and prevention of CSDS-induced anxiety-like behaviors in mice. A, B Quantitative analysis showing the preventive effect of minocycline pretreatment on acute MPL injection (400 μg/kg)-induced increases in the expression levels of IL-6 and IL-1β mRNA in the hippocampus and medial prefrontal cortex (n = 8, **p < 0.01 vs. vehicle; ##p < 0.01 vs. vehicle + MPL). C Timeline for the evaluation of minocycline pretreatment on the preventive effect of MPL on CSDS-induced anxiety-like behaviors in mice. D–F Quantitative analysis showing the effect of minocycline pretreatment on the time spent in open arms (D), the number of entries into open arms (E), and the number of entries into total arms (F) in the EPM test in mice treated with or without CSDS and/or MPL (n = 10, **p < 0.01 vs. vehicle; ##p < 0.01 vs. vehicle + CSDS; &&p < 0.01 vs. MPL + CSDS). G, H Quantitative analysis showing the effect of minocycline pretreatment on the time spent in lit side (G) and the number of total transitions (H) in both lit and dark side in the LDT in mice treated with or without CSDS and/or MPL (n = 10, *p < 0.05 vs. vehicle; ##p < 0.01 vs. vehicle + CSDS; &&p < 0.01 vs. MPL + CSDS). I, J Quantitative analysis showing the effect of minocycline pretreatment on the time spent in the center region of the open field (I) and the total distance (J) in the OFT in mice treated with or without CSDS and/or MPL (n = 10, **p < 0.01 vs. vehicle; ##p < 0.01 vs. vehicle + CSDS; &&p < 0.01 vs. MPL + CSDS). Data are shown as mean ± SEM. Comparisons were made by two-way ANOVA with (D, E, G, I) or without (F, H, J) Bonferroni test

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