Fig. 7

Effect of minocycline pretreatment on MPL-induced prevention of CSDS-induced neuroinflammatory responses in the brain. A–F Quantitative analysis showing the abrogation effect of minocycline pretreatment (40 mg/kg) on a single MPL injection (400 μg/kg, 1 day before stress exposure)-induced prevention of CSDS-induced increases in the levels of IL-1β (A hippocampus; D medial prefrontal cortex), IL-6 (B hippocampus; E medial prefrontal cortex), and TNF-α (C hippocampus; F cortex) in the hippocampus and medial prefrontal cortex (n = 10, **p < 0.01 vs. vehicle; ##p < 0.01 vs. vehicle + CSDS; &&p < 0.01 vs. MPL + CSDS). Data are shown as mean ± SEM. Comparisons were made by two-way ANOVA followed by Bonferroni test