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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Rasmussen’s encephalitis is characterized by relatively lower production of IFN-β and activated cytotoxic T cell upon herpes viruses infection

Fig. 3

The detection of GZMB in RE and TLE brain and its colocalization with CD8a-positive cells and MAP2-positive cells. A Sections from 30 RE, 20 TLE and 16 TBI brain samples were analyzed using immunohistochemistry (IHC) with antibodies against GZMB, and B were scored according to criteria described in the Materials and Methods and analyzed using a two-tailed Mann–Whitney U test (*: p < 0.05; **: p < 0.01, ns: non-significance). Bar: 50 μm. C and D Coimmunostaining with antibody against GZMB and antibodies against CD8a (C) or MAP2 (D). Cell nuclei were visualized with DAPI. Bar: 10 μm. E and F The GZMB (E) and sFasL (F) levels in brain tissue (n = 19) and cerebrospinal fluid (CSF) samples (n = 12) of patients were quantified by AimPlex Human Multiplex Immunoassays, expressed as mean ± STD and analyzed using a two-tailed Student t test (*: p < 0.05). G and H The microglia were detected with antibodies against Iba1, scored and analyzed using a two-tailed Mann–Whitney U test. Bar: 50 μm

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