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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Sublethal enteroviral infection exacerbates disease progression in an ALS mouse model

Fig. 4

CVB3 infection promotes proinflammatory responses in the CNS of SOD1G85R mice. AB Gene expression comparison of different proinflammatory cytokines/chemokines conducted using NanoString mouse immunology panel on the brain and spinal cord samples harvested from mock- (n = 3) and CVB3-infected SOD1G85R mice (n = 3) at week 20 PI. Panel (A) shows the Gene Ontology analysis of significantly expressed genes (p < 0.05, via student’s t test) in the brain (top) and spinal cord (bottom) of CVB3-infected SOD1G85R mice normalized to mock-infected counterparts. Panel (B) shows differentially expressed cytokine/chemokine genes (in relative Log2 fold changes) in the brain (top) and spinal cord (bottom) of CVB3-infected SOD1G85R mice normalized to mock-infected counterparts. C RT-qPCR validation of four significantly increased gene expression of TNFA, NFKB2, CXCL10 and CCL2 in the same brain samples (week 20 PI) as above. Quantifications are presented as mean ± SEM (n = 3–4 for each group). Statistical analysis was carried out using student’s t test. *, p < 0.05; **, p < 0.01

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