Fig. 4
From: TRPV4 contributes to ER stress and inflammation: implications for Parkinson’s disease
TRPV4 affected the number of Nissl-positive neurons in the SN. After infused with 0.5 μl AAV-TRPV4 shRNAi or 0.3 μl AAV-TRPV4 bilaterally into the SN of mice for 21 days and administrated with MPTP at 30 mg/kg/day for 7 days, representative sample of brain slices with Nissl staining showed Nissl-positive neurons in the SN. Knockdown of TRPV4 rescued the number of Nissl-positive neurons in the SN of PD mice, while upregulation of TRPV4 exacerbated the already reduction in the number of Nissl-positive neurons in the SN of PD mice (bar: 100 μm, n = 3). Data are presented as mean ± SEM. Significant differences: *P < 0.05, **P < 0.01, ***P < 0.001