Fig. 8

Schematic model indicated that AMPK-autophagy activation upregulated SOCS3 via the inhibition of microRNA-30a-5p by degrading DICER and AGO2. It suppressed morphine-induced neuroinflammation and improved analgesic tolerance
Schematic model indicated that AMPK-autophagy activation upregulated SOCS3 via the inhibition of microRNA-30a-5p by degrading DICER and AGO2. It suppressed morphine-induced neuroinflammation and improved analgesic tolerance