Fig. 2

CDC1551 i.c.vent.-infected Nos2^−/− mice demonstrated increased concentration of Th1-associated cytokines and chemokines, and neutrophil chemoattractants compared to C3HeB/FeJ infected mice at 8 week p.i. Concentrations of chemokines and cytokines in brain homogenates were normalised against total protein concentration. Statistical analysis performed using two way ANOVA with Sidak’s multiple comparisons test. Bars represent median and IQR. *, p < 0.05; **, p < 0.01; ***, p < 0.001. Nos2^−/− saline: n = 2; Nos2^−/− infected: n = 3; C3HeB/FeJ saline: n = 4; C3HeB/FeJ infected: n = 4