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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Nos2−/− mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis

Fig. 5

H37Rv infection of Nos2−/− mice by the i.c.vent. route resulted in significantly higher brain expression of inflammatory mediators than the i.v. route. H37Rv i.c.vent.-infected mice had higher concentrations of (ad) pro-inflammatory cytokines, (eh) Th1 chemokines, and (ik) neutrophil chemoattractants than H37Rv i.v. mice. Concentrations of inflammatory mediators in the brain were measured after day 21 p.i. Concentration of each immunological marker was normalised against the total protein concentration. Bars represent median and interquartile ranges. Statistical analysis was conducted using Mann–Whitney test. *, p < 0.05; **, p < 0.01. n = 6 mice were used per experimental group

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