Nos2−/− mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis

Table 2 Histopathological evaluation of M.tb-induced lesions in H37Rv-infected Nos2^−/− mice

Lesions^A	H37Rv i.v				H37Rv i.c.vent
Lesions^A	M	C	H	T	M	C	H	T
Inflammation (MNCs)	0	0	0	0	1	3	2	0
Perivascular cuffing		0	0	0		3	2	2
Gliosis		1	1	0		3	1	0
Granuloma		1	2	0		2	0	0
Pyrogranuloma		0	0	0		4	3	0
Neuronal degeneration/necrosis		0	0	0		2	1	0
Liquefactive necrosis ( ±)^B		+	+	−		+	+	−
Presence of bacilli ( ±)^B	−	−	+	−	−	+	+	−

M meninges, C cerebral cortex, H hippocampus, T thalamus
^ASeverity of lesions in each group are scored on a scale of 0–5: 0—no abnormalities detected; 1—minimal; 2—mild; 3—moderate; 4—marked; 5—severe. The average score of 5–6 mice per group is shown
^B± : present/absent

ISSN: 1742-2094