Fig. 6

β-arrestin 2, rather than β-arrestin 1 participates in the effects of fluoxetine on A1 reactive astrocytes. A, B Effects of β-arrestin 1 or β-arrestin 2 knockout on the levels of A1-special genes in astrocytes with or without fluoxetine treatment after A1 cocktail (A) or IL-6 (B) stimulation. Quantitative data are mean ± s.e. Data were analyzed using two-way ANOVA, then combined with Tukey’s multiple comparison to assess the differences between groups. All data represent the results of three independent experiments. *P < 0.05, and ***P < 0.001 vs respective Control cells treated with PBS; ^#P < 0.05, and ^###P < 0.001 vs WT Control cells treated with A1 (A) or IL-6 (B) stimulation; ^$P < 0.05, and ^$$$P < 0.001