Fig. 1

Treatment with 24A improved the neurological deficits of GCI/R mice. A Cerebral blood vessel of mice detected by three-dimensional time of flight magnetic resonance angiograph method. B The molecular structure of 24A. C The neurological deficit scores evaluated on the first, third, fifth and seventh days (n = 12, repeated measures ANOVA, p < 0.001). D, E Time (n = 12, repeated measures ANOVA, p < 0.001) and distance (n = 12, repeated measures ANOVA, p < 0.001) of the mice travelled to find the platform in the spatial exploration experiment of the MWM. F, G Frequency of the mice crossing over the target platform location (n = 12, one-way ANOVA, p = 0.001) and the time spent in the target platform quadrant (n = 12, one-way ANOVA, p = 0.040) in the directional navigation experiment of the MWM. H Representative trajectories in the directional navigation experiment of the MWM. (**p < 0.01, *p < 0.05, ns indicates no significant differences)