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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Neuroprotective effects of alisol A 24-acetate on cerebral ischaemia–reperfusion injury are mediated by regulating the PI3K/AKT pathway

Fig. 3

Treatment with 24A improved metabolism in different brain regions of GCI/R mice. Substance metabolism in the hippocampus and cortex was detected using MRS. A Typical spectra recorded from the hippocampus of mice. B, C Region of interest (ROI) in the mice hippocampus and cortex. DI Changes in the levels of the metabolites Glx (n = 6, Kruskal–Wallis test/one-way ANOVA, p hippocampus = 0.027, p cortex = 0.005), GABA (n = 6, one-way ANOVA, p hippocampus < 0.001, p cortex = 0.012), NAA (n = 6, one-way ANOVA, p hippocampus = 0.002, p cortex = 0.079), MI (n = 6, one-way ANOVA, p hippocampus < 0.001, p cortex = 0.041), CHO (n = 6, one-way ANOVA, p hippocampus = 0.003, p cortex = 0.033) and Taurine (n = 6, one-way ANOVA, p hippocampus < 0.001, p cortex < 0.001) in the hippocampus and cortex. (*p < 0.05 and **p < 0.01 compared with the sham group; ^p < 0.05 and ^^p < 0.01 compared with the GCI group; !p < 0.05 and !!p < 0.01 compared with the 24A intervention group)

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