Fig. 4

Lateral ventricle administration of BMSC-exos improved the AD-like behaviors induced by intracerebroventricular injection of STZ in mice. A Total ambulatory distance in the OFT. B Duration in the centre in the OFT. C Frequency to the central region in the OFT. D Moving distance in the central region in the OFT. E Number of rearing in the OFT. F Moving distance in the closed arm in the EPM. G Preference index of the novel object in the NOR. H Preference index of the novel arm in the Y-maze. I Immobility time in the TST. J Representative trajectories in OFT, EPM, Y-maze and NOR. K The duration in the centre in the OFT was positively correlated to the preference of novel object in the NOR. L The distance in the centre in the OFT was positively correlated to the preference of novel object in the NOR. M The number of rearing in the OFT was positively correlated to the preference of novel object in the NOR. Data are presented as means ± SEM, with n = 6 in each group (*P < 0.05, **P < 0.01)