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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer’s disease

Fig. 1

Effect of Gas6 overexpression on open field task and novel object recognition task. A Schematic of AAV-Gas6 construct containing full length Gas6 protein and AAV-control which contains an attenuated Gas6 sequence without the Gla and EGF domains. B Schematic of experimental design: APP/PS1 male and female mice received bilateral hippocampal injections of either AAV-Gas6 or AAV-control at 9 months of age. Behavioral tests were run 1 month later, and all mice were sacrificed at 10 months of age. C Mice were allowed to freely explore a 31 × 31 cm box for 5 min, during which distance travelled and time spent in the center of the box were quantified. N = 7–10 mice per group. Error bars represent mean ± SEM. Two-way ANOVA, #p = 0.0594, *p = 0.0225, **p = 0.0026. D Mice performed a novel object recognition task in which they were allowed to freely explore a box with two identical objects. Two hours later, they were exposed to one familiar object and one novel object, and time spent exploring each object was measured. Discrimination index: ((Time spent with novel object − Time spent with familiar object)/(Total time spent with both objects)). N = 7–10 mice per group. Error bars represent mean ± SEM

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