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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway

Fig. 10

Effect of EDA on Sirt1/Nrf2/HO-1/Gpx4 and TLR4/NF-κB signaling pathways. A Representative WB bands in the hippocampal region. BG Statistical graphs of relative protein expression of Sirt1 (B), Nrf2 (C), HO-1 (D), Gpx4 (E), TLR4 (F), and p-NF-κB (G). H Representative WB bands in the mPFC region. IN Statistical graphs of relative protein expression of Sirt1 (I), Nrf2 (J), HO-1 (K), Gpx4 (L), TLR4 (M), and p-NF-κB (N). Data are presented as mean ± SEM (n = 4 per group). *p < 0.05, **p < 0.01, ***p < 0.001 versus the CON + Vehicle group. #p < 0.05, ##p < 0.01, ###p < 0.001 versus the CSDS + Vehicle group

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