Fig. 10

Effect of EDA on Sirt1/Nrf2/HO-1/Gpx4 and TLR4/NF-κB signaling pathways. A Representative WB bands in the hippocampal region. B–G Statistical graphs of relative protein expression of Sirt1 (B), Nrf2 (C), HO-1 (D), Gpx4 (E), TLR4 (F), and p-NF-κB (G). H Representative WB bands in the mPFC region. I–N Statistical graphs of relative protein expression of Sirt1 (I), Nrf2 (J), HO-1 (K), Gpx4 (L), TLR4 (M), and p-NF-κB (N). Data are presented as mean ± SEM (n = 4 per group). *p < 0.05, **p < 0.01, ***p < 0.001 versus the CON + Vehicle group. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 versus the CSDS + Vehicle group