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Fig. 12 | Journal of Neuroinflammation

Fig. 12

From: Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway

Fig. 12

Blockade of Sirt1 abolished the antidepressant and anxiolytic effects of EDA. A Schematic timeline of the experimental procedure. B Social interaction test. C Sucrose preference test. D Open field test. E Elevated plus maze test. F Tail suspension test. G Forced swimming test. H Novel object recognition test. All the data are expressed as mean ± SEM (n = 8 per group). **p < 0.01, ***p < 0.001 versus the CON group. #p < 0.05, ##p < 0.01, ###p < 0.001 versus the CSDS group. &p < 0.05 versus the CSDS + EDA group

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