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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice

Fig. 7

Running exercise increased the total number of microglia in the DG of APP/PS1 mice. a Representative immunohistochemical staining of IBA1-labeled microglia in the DG, CA1, and CA3 regions of WT_Sed, AD_Sed, WT_Run, and AD_Run mice. Scale bar: 40 μm. b, c Quantification results of the total number and density of IBA1+ microglia in the DG, CA1, and CA3 regions of WT_Sed, AD_Sed, WT_Run, and AD_Run mice. d Representative binary images showing IBA1+ microglia with the uniform protocol in the DG of WT_Sed, AD_Sed, WT_Run, and AD_Run mice. e, f Quantification results of endpoints/microglia and process length/microglia. n = 4–5. Data are shown as the mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094