Fig. 8

Running exercise did not promote microglial proliferation in the hippocampus of APP/PS1 mice. a Representative immunofluorescence staining of BrdU (purple), IBA1 (red), and NeuN (green) in the hippocampus of WT_Sed, AD_Sed, WT_Run, and AD_Run mice. Scale bar: 40 μm. b Quantification results of the number of BrdU⁺ cells in the DG, CA1, and CA3 regions of WT_Sed, AD_Sed, WT_Run, and AD_Run mice. c Quantification results of the number of BrdU⁺/IBA1⁺ microglia in the DG, CA1, and CA3 regions of WT_Sed, AD_Sed, WT_Run, and AD_Run mice. n = 4–5. Data are shown as the mean ± SD, *p < 0.05, **p < 0.01, ***p < 0.001