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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Maresin 1 promotes nerve regeneration and alleviates neuropathic pain after nerve injury

Fig. 6

Maresin 1 regulated the PI3K–AKT–mTOR pathway. A, B Intraplantar injection of MaR1 did not affect the mechanical withdrawal threshold or paw withdrawal latency of normal mice, while NGF did. The data are presented as the mean ± SD, n = 6 mice in each group. *p < 0.05 MaR1 group verse the vehicle group; #p < 0.05 NGF group verse the vehicle group, two-way ANOVA and Bonferroni post hoc test. CF Western blot analysis indicated that the administration of MaR1 to ND7/23 cells for 60 min significantly activated the PI3K–AKT–mTOR pathway, while NGF promoted the expression of p-PI3K, p-AKT, p-mTOR and p-ERK, *p < 0.05, Student’s t-test and one-way ANOVA. G, H In vivo, western blot analysis of DRG neurons isolated from mice indicated that MaR1 significantly activated the PI3K–AKT–mTOR pathway, while NGF only promoted the expression of p-ERK. DRG neurons collected from the mice with MaR1 (500 ng), NGF (500 ng) or saline (vehicle) that administered using the sterile gelatin sponge to the injured region for 3 days. The data are presented as the mean ± SD, n = 3 mice in each group, Student’s t-test and one-way ANOVA test. *p < 0.05, **p < 0.01 verse vehicle group

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