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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Sox2 overexpression alleviates noise-induced hearing loss by inhibiting inflammation-related hair cell apoptosis

Fig. 4

Sox2 overexpression suppressed noise-induced HC apoptosis. A Representative images of PI-stained OHC nuclei in the cochlear epithelium. Both swollen and condensed OHC nuclei were observed in mice treated with noise exposure. Arrowheads point to swollen necrotic nuclei, and arrows point to condensed apoptotic nuclei. B The numbers of swollen or condensed OHC nuclei and missing OHCs in the cochlear epithelium at 6 h after noise exposure. C Representative images of TUNEL staining and Myosin7a immunofluorescence of the cochlear epithelium. TUNEL+/Myosin7a+ OHCs were observed in the mouse cochlea at 6 h after noise exposure. D Quantification of TUNEL+/Myosin7a+ HCs in the cochlear epithelium. Data are presented as means ± SEM.; n = 6. *P < 0.05, **P < 0.01. Scale bar = 20 μm

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