Skip to main content
Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis

Fig. 1

A2AR signals located on the choroid plexus were increased in the EAE model. A Following EAE induction in WT mice, the immunofluorescent staining of A2AR, ICAM1 and CD3 was performed at day 0, 4, 8, 12, and 16 after immunization. Scale bar, 100 µm (n = 3/group). B The clinical scores of EAE mice in A (n = 20). C The fluorescence quantification of A2AR in A (n = 3/group). One-way ANOVA, Tukey’s multiple comparisons test. D–H The mRNA analysis of adora2a (A2AR), icam1, ccl2, ccl5 and cxcl10 at day 0 (n = 3), 4 (n = 5), 8 (n = 6), 12 (n = 7), and 16 (n = 5) post-immunization. I Regression analysis between the numbers of CD3+ T cells recruited to the CP tissue and mRNA level of adora2a (A2AR) (n = 14). *p < 0.05, **p < 0.01 and ***p < 0.001

Back to article page