Fig. 2

Scotopic electroretinogram response is selectively reduced in the active phase of bMOG EAE. ERGs were recorded at days 16 and 32 after EAE induction. A Representative ERG waves are shown on day 16. B In EAE mice (n = 14), luminance-response curves showed significant reduction in b-wave and a-wave ERG amplitudes compared with CFA (n = 10) and naive (n = 12) control animals in the active phase of the disease (day 16), as identified in Fig. 1. Peak times were not significantly affected. C At 32 days post-bMOG injection, ERG wave amplitudes did not statistically change in EAE mice (n = 16) when compared to controls, i.e., CFA-treated (n = 16) or naive (n = 6) mice. No significant changes were noticed for peak time measurements. Statistics: two-way ANOVA, Tukey post hoc test; *: P < 0.05, **: P < 0.01, ***: P < 0.001, ****: P < 0.0001. Green stars indicate statistical significance between EAE and CFA-treated mice. Blue stars indicate statistical significance between EAE and naive mice