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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Neuronal FcεRIα directly mediates ocular itch via IgE-immune complex in a mouse model of allergic conjunctivitis

Fig. 1

Analysis of FcεRIα expression in conjunctiva-innervating sensory neurons. A Double-immunostaining showed that FcεRIα signal was colocalized with the neuronal marker PGP9.5 in the trigeminal ganglion of mice. Scale bar: 100 μm. B FcεRIα was detected in PGP9.5+ neuronal fiber in the conjunctiva of mice. Scale bar: 25 μm. C Double-immunostaining showed that FcεRIα signal was colocalized with the neuronal marker PGP9.5 in the trigeminal ganglion of human. Scale bar: 100 μm. D Expression pattern of FcεRIα along different sizes trigeminal neurons in human trigeminal ganglion. E Fluorescent immunostaining in WGA-labeled (blue) TG for FcεRIα (green) and markers (red) including NF200 (n = 4 mice), IB4 (n = 4 mice), CGRP (n = 4 mice), and glutamine synthetase (GS; n = 4 mice), along with quantitative analysis of percentage overlap. Scale bars: 100 μm

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