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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression

Fig. 7

Graphic summary: Characterisation of ALS MDMi and pathological pathways for potential microglia targeted therapy. Blood monocytes derived from ALS patient PBMCs were successfully cultured to microglia-like cells (monocyte-derived microglia, MDMi). ALS MDMi recapitulated hallmarks of ALS pathology, including cytoplasmic TDP-43 localisation and phosphorylated (p)-TDP-43 inclusions. A range of abnormalities including microglial activation, altered cytokine expression, and decreased phagocytosis was observed in ALS MDMi compared to HC MDMi. MDMi model is highly suited to investigate patient heterogeneity, drug screening, and providing a basis for automated drug screening platforms in ALS and other neurodegenerative diseases

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Journal of Neuroinflammation

ISSN: 1742-2094